Here is a breakdown of what is currently happening in the fight against fentynal 1. Enforcement and Seizures (Supply Side) Record Seizures: CBP has seized more fentanyl in the last two years than in the previous five years combined. In 2025, the DEA reported seizing over 47 million fentanyl-laced pills and nearly 10,000 pounds of powder. Targeting Supply Chains (Operation Apollo): Federal agencies (CBP, HSI) have transitioned from simple border seizures to dismantling supply chains, particularly targeting precursor chemicals coming from Asia to Mexico. Operation Apollo and Operation Plaza Spike are key multi-agency efforts targeting traffickers in Southern California and Arizona. International Cooperation: The U.S. is working with Mexico and China to interdict precursor chemicals. In July 2024, a major seizure of precursor chemicals occurred at the port of Manzanillo, Mexico. Combating “E-Commerce” Drug Trade: Traffickers are increasingly using the internet and social media to sell drugs, making them harder to trace than traditional street dealing.